Platelet glycoprotein VI as a mediator of metastasis
نویسندگان
چکیده
منابع مشابه
Variation in human platelet glycoprotein VI content modulates glycoprotein VI-specific prothrombinase activity.
- Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen that figures prominently in signal transduction. An addition to binding to type I and III collagens, GPVI is also bound specifically by collagen-related peptide and convulxin (CVX), a snake venom protein. We developed a quantitative assay of platelet GPVI in which biotin-conjugated CVX binds selectively to GPVI in separated t...
متن کاملGlycoprotein VI Dimerization as a Novel Checkpoint and Early Biomarker of Platelet Activation
Platelet adhesion, activation, and aggregation at sites of vascular injury are crucial for normal hemostasis but may also lead to occlusion of diseased vessels, resulting in myocardial infarction or ischemic stroke.1,2 The extracellular matrix protein collagen is the major and most thrombogenic component of the vessel wall, as it provides an adhesion substrate for platelets and directly activat...
متن کاملMeasuring soluble platelet glycoprotein VI in human plasma by ELISA.
Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies or activation at the platelet Fc receptor, FcgammaRIIa. This raises the questi...
متن کاملAlboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib.
The snake venom C-type lectin alboaggregin A (or 50-kd alboaggregin) from Trimeresurus albolabris was previously shown to be a platelet glycoprotein (GP) Ib agonist. However, investigations of the signal transduction induced in platelets showed patterns of tyrosine phosphorylation that were different from those of other GPIb agonists and suggested the presence of an additional receptor. In this...
متن کاملPlatelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity.
OBJECTIVE The immune receptor homologue glycoprotein VI (GPVI)/FcR receptor γ chain complex is primarily responsible for platelet activation by collagen. There is growing evidence that optimal binding of GPVI to collagen depends on the assembly of GPVI dimers. The valence of GPVI on resting platelets needs to be clearly established because platelet avidity for collagen would be greater if GPVI ...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2009
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2009.03566.x